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Watch Closely (one)pentobarbital will decrease the level or effect of cannabidiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital raises effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers might raise metabolism of ifosfamide to it